In a blockchain job interview, candidates should be ready to answer questions about their understanding of the Web3 ecosystem, experience with blockchain technologies, contributions to DApps and smart contracts, problem-solving skills, and ability to address security and scalability challenges. The interviewer may ask about practical applications of the technology and how candidates have addressed security and scalability challenges in Web3 projects. Soft skills such as problem-solving and teamwork are also valued in the Web3 industry, and expressing enthusiasm for the technology can make a candidate stand out.